It is an interesting question, But no in general they don't seem to be different male to female but they do have personalities and temperament vary snake to snake. I have one neurotic male and female, very nervous and not very hand-able. There are 3 (2f,1m) very very easy to handle and 2 (1m2f) curious ones that are very easy to handle but are interested in anything new, (I have to keep and eye on coffee one seems to be attracted to hot mugs )

I have been speaking with a reptile keeper at a zoo and he believes that in pythons temperament is partially genetic. I have seen so evidence to support this. I have encounter a ball python that is very snappy quite ready to strike, an odd ball I thought. An other person bought a snake from that same breeder and it too is the same.

The zoo guy has been breeding African Rock Pythons that in general have a nasty rep. He encountered a fairy docile specimen and has had this idea that about temperament and spent 2 days and a bunch of bits but found a second rock that is docile. They bred them and I have handled a 12 foot rock that acted more like a big boa, very chill and not aggressive at all. The litter is mostly the same they have held back the most easy going ones to continue the project I hope that in a few years they will be able to 'prove' it out.