I'm fine with hybrids, given the animals are not released into the wild for any reason, the breeding does not result in severe defects that affect the animal's quality of life, etc.
The whole "screwing with mother nature" bit is not exactly a good point against hybridization. We are not creating hybrids and releasing them into the wild to form wild populations and ultimately screw up the ecosystem of that habitat. People that breed for hybrids do it for their own personal captive collections or those of other people. I don't consider the snakes I have here to be "mother nature". These are captive bred and hatched snakes and will never be released into the wild, and neither will their offspring. They are a captive population.
I may or may not get a hybrid or breed hybrids in the future. I haven't done a lot of looking into them and to be honest, I haven't even seen pictures of hybrids. I just have not looked. For now, I'm content to have my balls be balls, and my corns be corns.