When my female goes into hardcore shed, she digs all the way down to the substrate under the water bowl. And stays there for a few days. She just acts indifferent toward everything, because when I pick up the water bowl to refill it and check on her she just sits there and looks at me like, "can you put that back please? kthanx." She's never hissed at me though.

My bf's male on the other hand, if you get NEAR his tank when he goes into a big shed he'll hiss and get pissy. Never strike, but he'll throw a fit. This includes going to turn the fogger on, turning on and off lights, and moving a hand in front of the tank. He's usually only that bad for the first day and a half-ish. Then just stays in his hide with his body over his head until he's done shedding.