It's really not that big of a deal. I haven't bred sibling ball pythons together, but I've bred Father to Daughter or Son to Mother several times without any problems. I've also been breeding corn snakes for over 20 years and I have a line of ghost corns that have been inbred over several generations without any problems cropping up. Obviously if you DO encounter any problems you shouldn't use any of those offspring for future breeders or breed the same pair together again, but the chances are pretty slim that you will actually encounter any problems.
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