A self rat as far as I know cannot create megacolon since they don';t carry the high white gene.
Megacolon is when the fetus doesn't develop it's nervous system far enough around the body to reach the colon, making the colon unable to push food through, making the rattie bloat and die.
When two high white genes meet this is the cause, if there is another cause I'm not privy to the information
Odd-eye, Dalmatians, variegated, head spots, blazes, possum faces, lightning blazes and maybe more are all rats that carry the high white gene.
Maybe your rattie was an odd-eye with a pink and a red eye?
I've had about 60+ litters the last 2 years and have had not one megacolon rat, self to blazes all day long and you'll never make one as long as you remember that rule.
Odd-eye Blue berkshire standard coat.
One Ruby eye one black eye, this rat would definitely need to breed to a self female or pay the price
Black Variegated blazed standard coat
Black Berkshire Blazed standard coat.
Blue Berkshire blaze standard coat.
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