Throw it in, and let the snake do his thing! Seriously, that's about all there is to it... but as the others mentioned, you do have to supervise & remove it within 15-20 minutes if they don't eat. I feed all of my BPs live mice (the colubrids & Australian pythons usually get f/t) in their enclosures, and haven't had a feeding "accident" or incident yet. It takes a good 30-45 minutes to feed and supervise everyone, especially since most of them get multiple mice... but I still find it easier than frozen, and waste less than I do with f/t prey. Good luck!