Don't fret over a hiss, just pick the little guy up. I've had my spider for roughly 6 months or more and he's hissed at me several times upon first picking him up. I just acquired a new, beautiful Mojave male who is about 1.5 years old and HE hisses at me LOUD from time to time when I go to pick him up. it doesn't mean they're going to bite you...well, not necessarily anyway...