I was cleaning a tank and absentmindedly brushed my hand against a rock anemone. Didn't feel anything at the time, but a day later my hand was tingly and hurt. Day after that it was red and itchy. It took at least a week for the rash to go away and things to feel back to normal.
I also learned about a year ago about palytoxins. Palythoas and zoanthids are one of the most common pieces you'll find in reef tanks (IMO) just because they're beautiful and not terribly expensive. They secrete palytoxins when they're stressed or injured and this is apparently one of the most toxic organic substances known! I read through a thread on Reef Central a while back that detailed sickness in some people exposed to the toxin (through cuts or scrapes on your hand) and a story about a dog who died after eating some zoanthids.
Needless to say, I've learned my lesson and latex gloves are a good thing.
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