As far as handling her as long as she has settled in nicely there shouldn't be any worries as far as handling her. Just don't over due it. I have a Mojave that is alittle snippy and I have just got into the habit of removing her hide and comeing from the back side of her to pick her up. My hand doesn't go head on to her or she will tag me.
Most of the time snakes will get all the water they need from their prey. I have had mine for over a year and I have only seen them actually drinking twice.