here, let me grab some of those sites.
I've never bred rats myself, but have kept them as pets and i know a few people who have their own ratteries. (pet rats)
http://www.ratfanclub.org/megacolon.html
http://ratguide.com/health/digestive/megacolon.php
http://www.spoiledratten.com/medicalcontent.html
Those are the sites i've gotten most of my info from. Blues also seem to be at a higher risk for health issues.