Sanitizer if I can't get to a sink and at shows, soap and water any other time. Generally I'm not too careful at all, but I've got a few animals in quarantine, and I don't want to pass anything between snakes. If I'm not handling the snakes, (i.e. working at a farm I volunteer at or playing with my dogs) I'm not careful at all. If my hands feel dirty, I'll wash them, but most of the time I forget. And haven't gotten sick yet, thank goodness