The ones I've come across aren't the nicest, but I haven't really come across many of them besides the ones at the reptile sanctuary. The BRBs there are mean, they snap, and they bite (they are still babies). We have a baby Columbian but he's snappy, and so are some of the adults (besides only one of them that I handled).

You can find pretty docile ones I'm sure, and regular handling would be necessary. They definitely aren't for beginners because of their enclosure requirements (humidity is the biggy) but they do make awesome pets.