Well, not everyone is comfortable smashing an animal's head, or sticking something in the skull and "scrambling" the brain.
That's why my favorite is the GUN. one shot, no matter from WHAT firearm, and you're almost guaranteed to either blow the whole head to smithereens, or destroy the whole brain in one shot. it's FAST, and painless. if the snake twitches afterwards it's just a muscular reaction, but the brain is done for so it can't "feel" ANYTHING.