I think they get used to your scent, but nothing more than that. I just left my snakes for a whole week, and when I got home I picked them all up to inspect them. My pastel took a min to warm up to me. The pinstripe surprisingly didn't hiss, but just wanted food. And the Het Pied wouldn't let me pick him up. He was following my hands like they were rats, he was clearly upset he didn't get fed for one week.

For the most part, they both act the same way whether it's me or my BF holding them.