I don't mean to be weird, but the proliferation of pet snakes in the wild is well documented. Look at Florida for example. I don't think our snakes would have any trouble adapting to the wild. The ones that did have trouble would be eliminated from the population, and the ones that were fine would go off and have babies--that's just how it works. Given we cannot be sure our animals wouldn't cary with them foreign parasites and diseases, but a part of me doubts this. If any harm were to be done, I imagine it would be an issue of our snakes not having the antibodies needed to survive in Africa, and again, natural selection would iron this out over time. As far as goes collecting snakes in Africa, I can see how it could potentially become a problem. As it stands right now, I think the highest demand is on crazy phenotypes, and stresses on Normal populations aren't that great for the pet trade. Ball Pythons seem to have a relatively high fecundity. If females are reproducing from 2 years old, laying 6-10 eggs per clutch every year for 20 or so years (I imagine this is a ripe old age for a wild snake), that's at least 100-200+ babies over a snakes lifetime. Obviously this isn't sea turtle like fecundity, but, given the snakes hide-in-burrow lifestyle, I'd be willing to bet at least 10-25 of those 100+ survive into adulthood to reproduce. While this doesn't seem like a lot, I don't think we're yet collecting 10-25 normals for every breeding snake out there, as the demand just isn't there for normals like that, so I'd say we're okay right now. I'd also have to disagree with the OP and say that I'm pretty positive new crazy morphs will be found in Africa, new stuff has been discovered consistently over the years. Anywho, none of this is meant to be abrasive to anyone, it's all just my own opinion. I'm in no way an expert in any of these subjects though, so my opinion should be taken with a grain of salt.

Cheers,
-Matt