everyone does it(with their feeders and snakes).
i started with a few rats and every litter i hold back more for breeding. no ill effects to date(though ive only been breeding a short time) but in all honesty my buddy has been breeding for years and never buys new bloodlines and he maybe gets a tumor case once every 200 rats. which is pretty good. he does get the occasional deformity such as no legs blind ect ect. but all that could get chocked up to prenatal problems in individual rats. so i say do it
adam jeffery