With my guy i only rated 5 days after he settled in then i would hold him. But sometime he would hiss as i was trying to pick him up but never bite me. Then after i got him out i would just let him roam through my fingers for about 30 mins put him back after about a week never hissed again. Try that. Honestly if you think about it how long is it gonna take a snake to get acclimated to a 20L if you get my drift.