My older is going through shed right now, her belly gets super pink, I don't like bothering them, looks like they had a terrible sunburn, and she acts like if she just had a horrible hangover...She's really tame, so I'm lucky with that. I did spot clean, and she never has a problem with that.
On the other hand, my other guy lets me know when he doesn't want to be bothered, and so if its not necessary, I leave him alone...