It's amazing how often this question comes up and the mixed responses.

I have a 55 gal tank and have a very happy snake and no environment issues.
He eats like a champ (in a separate feeding container...another topic of much discussion). I barely get the rat into his feeding container and he's all over it.
The tank is mostly enclosed with wood on the outside keeping an insulating barrier between the glass and wood.
The CHE's are set to the same thermostat that runs the UTH...so consistent heat above and below. Ambient is 82 with belly at 90 in the warm hide.
The air vent allows me to open and close to retain humidity (which runs consistent 50%..except when I spray a little during sheds).
He moved into this tank at about 1 year old...no problems.

I never see him during the day, but he cruises at night.

He has never as much as hissed at me. He gets handled frequently and has since the very beginning so he would get used to it.

In my opinion, at the end of the day, if you can provide the necessary needs of your snake and maintain a healthy environment, then go for it.