I keep records of when mine shed so I know when to expect the next one. When I first notice the pink belly I will go ahead and clean the enclosure, raise the humidity then just leave them alone until they are done. If I do have to handle them in order to clean out poop or anything I just try to be gentle. If I can get by with a spot cleaning then I just place a towel over their hide so there is less of a chance of them striking at me...
Rob