I know that it sucks, I was unemployed for a full year after 9-11. My company cut worldwide employees from 90K to down to 40K.
Here's what I did. I registered with as many temp agencies as I could who hired for the type of positions that I was looking for. I networked with people (look to see if there's a meeting at a local church, specifically geared towards job hunting and networking). I had one day a week that I looked forward to as my "reward" for all my job hunting - and that was doing weekly outings with Canine Assistants every Wednesday night. It would be a group of volunteers that would meet up at 5, get the dogs bathed, packed up with their "Please don't pet me, I'm working" packs, and go out for dinner, or go to a movie, etc.
I called every temp agency that I was registered with every Monday, and I made at least 5 calls a day to other jobs that I would find advertised.
One day I got a call from a head hunter for the position that I'm in now. My unemployment benefits ran out the Friday before the new job started. Talk about timing!
Try to stay positive, I know how hard that can be. Do NOT beat yourself up over rejections, it's not about you - there's a of people competing for the same jobs, unfortunately. Follow up after every interview with a hand written thank you note for their time, and reiterate how excited you are at the prospect of working there.
The right job will come!