It's a mutation and a phenotype. Piebaldism stems from a defect in neural crest development during embryogenesis. This defect affects distribution of melanocytes which causes the white patches that you see in humans, rats, horses, (and we assume) snakes, etc. Usually, the more white you see in mammals, the more severe the neurological disorders. That's why breeding for high white in horses is discouraged. I wouldn't be surprised if pied BPs have some sort of disorder that we're not aware of. They certainly can't tell us if they're having visual disturbances or digestive issues. Or, the mutation may be quite benign. It depends on which gene and where along the gene the mutation is located, or if more than one mutated gene is working in tandem with another. I've heard complaints from some breeders that their pieds are picky eaters. If this turns out to be a common complaint, there might be evidence that there is some consequence of this mutation. Hope this helps.Originally Posted by MsPrada
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