I have a few friends that had giants. They were not nervous about handling them, but were respectful and careful. Some snakes need a second person to lift them into a cage, some do not. Some keepers will only keep giants if they have that second person, while others feel no need for such.

If the keeper can handle the animal, and has a proper enclosure for it, it's no more of an issue than keeping a large dog. Both COULD injure other people IF they wanted to/were startled. But it's the keeper who determines how to best handle them to make the animal and people safe and healthy.

All above only my opinion, subject to change without notice, contents measured by weight, not volumne.