Not necessarily.
I don't think ball pythons ball up because of stress at all. Hence their name 'ball pythons' they will ball up when they are frightened or concerned about their surroundings.
I would be concerned if an animal 100x my size picked me up and tried to play with me too. A perfectly stress free snake can ball up because it is afraid of the owner. I personally only have 2/6 that will frequently ball up, but it really depends on the snake. All are in the same set-up, temps, and eat each week like clockwork.