Driving is just fine. Put the snake in a pillowcase, and then in a ventilated box.

keep temps between 65 and high 80s. Watch out for direct car heating/air conditioning making temps too extreme.

If possible have the permanent home set-up with temps and humidity stabalized before you move.

Most hotels don't allow animals but you can probably sneak your snake in, it's not like they bark or anything. Don't leave your snake in a car unattended, temps can fluctuate quickly without someone around monitoring.

It's late and I'm a little fuzzy headed but that's a start for you. Ball pythons are hardy and tolerate less than ideal temperatures for a day or two with little issue. Just imagine all the stress that they go through being shipped through the mail.