I recently found out that our local city pound gets a fair number of herps turned in, and has zero adoption program for them...if a shelter employee doesn't want one, they get euthed.

Right now, there is no official rescue in the state that I am aware of...there is one girl locally who tries hard, but pays for all the medical care at full price out of her own pocket, and thus is limited financially in what she can take on (plus I don't think she has much room to house them). And she has no web presence at all for getting them adopted out...she relies on word of mouth.
So I've been talking with a couple of other vet techs who also have significant herp experience about starting a rescue.

One girl has a committed husband who loves larger snakes, and she breeds and sells feeders...so we'd have a food source for snakes anyway.

I will be starting work this month or the next at a vet hospital that sees a lot of exotics, including reptiles, which I'm really excited about...so I'll have that as a resource to draw on.

Obviously, there will need to be some pretty strict quarantine protocols in place. I have a spare room I can use that is down the hall from my collection.

Also, I would expect to see a lot of malnourished/poor husbandry issues. I have zero experience with lizards or torts, but I'm sure I can find the information I would need. I am capable and comfortable with basic parasite control, giving injections, tube-feeding, etc.

We can easily get registered with Petfinder (I've done it before) and thus get exposure for adoptable animals. I need to get off my butt about FedEx shipping certification, and then we'll be able to adopt them out anywhere in the US.

What issues am I missing, or need more consideration?

What species and cases would I be most likely to see?

This is still just an idea...I haven't begun to take any steps to make it happen yet, beyond asking my fellow vet techs if they would be interested (they are, very much so). I don't want to leap into this and then find out too late that I can't handle it, or didn't prepare myself for a situation. I've done a ton of cat and dog rescue, and right now I just don't have the attention required to fostor and socialize a mammal. I'm thinking that herps would be easier in that respect, and there is a definite need for it in this area.