About a year ago my ball python started wheezing. At first it was barely noticable, then I realized it happened with nearly every breath. Took her to the vet, got the shots, administered them as instructed. Still wheezing! Turns out my husbandry was waaayyyy off (had not yet found these boards, just went by a few caresheets online)... she was too cold, and way too dry. So this summer I've gotten her humidity up, and temps correct (though still fiddling with that) and she hasn't wheezed at all in a few months now.

Though sometimes she does let out a deep breath, but I don't think that's anything to worry about. Kinda just like how they randomly yawn, right?