Probably not much different than keeping a male/female adult pair together, minus breeding activity, and that size discrepancy will diminish over time. My female infernalis is massive compared to my male and they are housed together. They will try to steal food from each other so I always make sure to get them eating simultaneously with a backup morsel in case one finishes far ahead of the other to keep them occupied. You'll learn which is your faster/greedier feeder pretty quick so you can always give that one a slightly larger meal or offer it sideways to slow them down a bit. As they're very visual critters, I can even use my finger to lure the first one done away from the other without much trouble. I'm always a little surprised when my male doesn't get gobbled up during pregnancy as the female's greed for food increases tenfold. Just supervise feeding closely and I doubt you'll have any issues. I also raise newborns(Thamnophis give live birth - viviparous) in groups as I find them easier to get feeding consistently on prepared diet this way. There's definitely a competitive streak with these snakes when it comes to food. Once one hits the feeding station, everyone in the vicinity is usually close to follow.
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