I still pick the hissy or skittish ones up, making sure I fully support them. I start handling sessions short, 10-15 minutes tops, so that they have some time to get used to handling and learn I’m not going to eat them. I usually sit on the couch with them on my lap and let them explore a bit, gently guiding them with my hands. I try not to get near their heads to start with since many are head shy, there’s plenty of time to work on that later. They typically relax and will explore a bit, then you can put them back in their enclosure on a positive note...they got to explore and nothing hurt them. Patience and gentle handling eventually win them over, though some may always make a little noise when you first go to take them out.