Sorry I was a bit TL;DR there but the fact stands: if handling in regular intervals at controlled amounts wasn't leading to a stressed, huffy, fasting BP, the animal is likely inclined enough toward "favoring" or "tolerating" humans that handling it once a week won't cause any concerns. It's more likely that the husbandry may slip if you're not able to regularly check in on the animal, leading to THOSE factors causing stress and a loss of "tameness".
Long as you keep the snake truly comfortable and don't leave it for months other than feedings, it should be fine.