Inbreeding depression happens in plants and insects. It's not just an issue with mammals.
I would imagine that if a high COI caused reproduction issues and failure to thrive in corn, fruit flies, and rats that it might be a good idea to keep that percentage down in snakes too.
The occasional line breeding is fine. A few sibling breedings here and there, breeding off spring back to its parent - it's not like you are going to have deformed clutches in one breeding season. Probably not even 2 or 3. Heck maybe not even more after that. But still, i think it might be best to avoid inbreeding generation after generation. Out crossing every so often for genetic diversity seems to be a good bet for most living things.
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