The answer is truly, it depends.
I handle my 13' 8" Purple Albino solo a lot. I usually have my wife home, but I use to do it with no one home all the time. Is it the safest way? No. But if she urinates everywhere and needs a clean cage do I wait till someone is able to be there, again no. But when I'm doing cleaning its not about handling an animal and just letting her run around. I only do that with other people around due to the nature of the situation. But as far as cleaning / feeding goes, I get a giant tub, and move her into the tub while I clean her cage. Then grab her and move her back in - again its my personal preference in this matter.
Rule of thumb is a second person is needed at 12 ft (you need 1 person per 6 ft - but many wait till you're at the max spectrum to mandate the second person.
If you read death reports from giant constrictors, usually a few things are common.
1) Alcohol was involved
2) Live feeding was involved
3) Cages were left open
Bites happen, its part of the game, but most if not all fatalities occur due to one of the three reasons above or a combination of all.
Cheers
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