Depends on the snake. I have a Mohave male that likes to pop out of his tub and climb into my hair. So, he gets handled a lot by default. Others vary from merely tolerating handling to being actively pissy/hissy when you pull them out of the tub, and one will strike but is improving. I actually try to handle the pissy or defensive ones more often, in addition to removing them for tub cleaning, just for a minute or two until they settle, and then I put them back.
Two of the boas get handled a lot because when the enclosure door is opened they often come out of their enclosures, onto my shoulder, and up toward the ceiling fan - all my boas are fascinated by it even when it's turned off.
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