The Petsmart website is referring to how much to mix to treat fish tanks. The only time I ever used it I used 1 pack to each 20oz bottle. 1 packet per 16-20oz is a whole lot different than one packet to 1280oz (or one packet to 128oz if you meant using all ten packets in the box to treat ten gallons). You have to mix it a little stronger for usage as a rat drink vs a fishs water.