Comfort in your had is the first priority as most have stated.
I think almost everyone hase giving great information.
My wife carries a S&W Mod 60 LS and loves it, two speed loaders and she is good with 14 rounds
I bounce between a Ruger P89, S&W .40 Sigma or CZ Mod 83.
We are both thinking of getting our CHLs but the Castle Laws here are great and I chose to carry on me either way.

The biggest thing to remember is IF you pull your weapon you better be 100% clear that you are about to make someone stop breathing. If you cannot handle that though then you probably shouldnt carry a gun that will more that likely get taken from you and used on you.