I don't see anything wrong with giving it a go. I think they are cool snakes, but I do understand where some people are coming from in terms of being responsible. For example, I've bred axolotls for years and the axolotl has become so interbred with other species of salamander, morphs, etc. that it is now nothing like it was in the wild. Which is really a shame because they are now virtually extinct in the wild, but the captive specimens are impossible to reintroduce (because they have changed so much from the original species).
In other words I think some people are afraid that hybriding will become so popular that eventually a ball python will really be part blood, or someone buys a ball and later finds out its part blood python.
I understand both sides, but to each their own.