No, you will definitely need to clean the tank completely. Spot cleaning is okay in between cleanings but like ScottNBecky said at the very least 4-6 weeks it should be cleaned and disinfected. Being a hot and humid environment it is a great place for bacteria to live and thrive unfortunately. For my one tank and my tubs I just fill a spray bottle with water/bleach solution, rinse them all out in my shower, spray them down with the bleach/water, do a little scrubbing (mae sure you get the corners and edges well) and then rinse them a few times.
I use aspen bedding, makes spot cleaning so much easier since it's light, and you can clearly see when it's wet, and I don't have to dig through dark bedding to find poo.
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