I have a few dozen blue females (het dumbo) that will be popping out blue dumbos for me pretty soon.
Blue is just the color. The gene associated with color has NOTHING to do with reproductive capacity.
Blue rats, if bred appropriately, have no more problems than any other colors.
By this time next year my entire colony will be blue dumbos.
I don't anticipate ANY problems.
When you breed a bad rat to a bad rat (no matter what color) you will have problems. When you breed a good rat to a good rat you get good babies.