So how many people feed little and often and how many feed larger and less frequent? My animals tend to have 1 larger prey item weekly and they seem to grow at a similar rate to animals fed smaller items every 4 days or so, so it seems there's not a huge difference.
Little is in the eyes of the beholder, lol.
When I feed two prey items the weight of those two is more than the "appropriate size" single item they could eat in one meal, so they gain more than what one meal would give them.
This only works if they continue to eat

I prefer this as it means my animals are normally empty come feeding time so usually feed more consistantly, there is less frequent cleaning out required and of course, it works out cheaper!
Breeding your own rats takes the cost factor out, unless your feeding hundreds of snakes, lol.

Also, has anyone studied the weight gain from different food items? I've heard it's typically 20% for mice, 30% for rats and 40% for multis (ASFs)? That means for every 100g of mice you feed, the weight gain is only 20g compared to 30g for 100g of rats and 40g for 100g of multis.
I noticed that mice sucked when I first got into ball pythons, so I have never fed mice since then.

I haven't noticed the difference in weight gain per type of prey because I switch mine over to rats as soon as I can.
I start hatchlings with asf's because they readily take them, then it's all rats all of the time.

Wow Freaky frog that's some killer weight gain