I have no problem with hybrids. Although I would probably never own one. I love the temperment of a ball, mixing that with the moodyness of other pythons just would not fit in my family.
I would also never own a wold hybrid (I do have small food sized children, and their safety comes first)

But the way I feel is if they will breed when put together, without having to have "help" to do what comes natural, than it "could" happen in the wild (other than those on different continents)

after all wolves are breeding with coyotes, and people want to kill all the hybrids, but that would be nature just evolving.
also polar bears and grizzly bears are creating hybrids.

Although part of me wants man to just stay out of mother natures business.