I'm not an expert by any means, but being in shed hasn't seemed to affect any of my snakes libido. I say give it a shot--if they seem stressed and/or don't want to lock, separate them until the snake sheds, and try again. I've had both males and females breed while in the blue though, and it has never seemed to hinder their breeding efforts. Good luck!
*note, I should really be asleep*
Cheers,
-Matt
R.I.P. Steve, I'll miss you more than you could have ever known. I love you.