Re: Ivory/Albino Paradox? Chimera? What is this thing?
Quote:
Originally Posted by
nicolerc
This is close to what we believe as well, but it's obviously less likely that both parents are hidden hets rather than just one or the other.
While it may be less likely that both parents were unknown hets it is even more unlikely that you would see a case of a mosaic with regionalized alternating monoallelism happening so that you get patches that are entirely Albino/YB and patches that are entirely non-Albino/Ivory but no patches that are non-Albino/YB or Albino/Ivory
Quote:
Originally Posted by
nicolerc
I'm not sure if there were fire siblings or not, but it shouldn't matter if there were. She was bred to both males and siblings could have been sired by either.
Superficially, yes it does not matter. But, if in all the other siblings there are no Fire or WT then the statistical odds of this one animal being from a different sire are much reduced. And if you can pin down the likely father then you can consider proving it out as het Albino at some later date.
Re: Ivory/Albino Paradox? Chimera? What is this thing?
Quote:
Originally Posted by
asplundii
While it may be less likely that both parents were unknown hets it is even more unlikely that you would see a case of a mosaic with regionalized alternating monoallelism happening so that you get patches that are entirely Albino/YB and patches that are entirely non-Albino/Ivory but no patches that are non-Albino/YB or Albino/Ivory
For those of us that are big word challenged (like me), are you saying that it is more likely the both parents were het albino since there appears to be a lack of pattern consistent with a normal patterned animal?
Re: Ivory/Albino Paradox? Chimera? What is this thing?
Quote:
Originally Posted by
JodanOrNoDan
For those of us that are big word challenged (like me), are you saying that it is more likely the both parents were het albino since there appears to be a lack of pattern consistent with a normal patterned animal?
LOL... Sorry, I lapsed into jargon there didn't I? Let me try again.
In a mosaic-type paradox, you have a situation where one of the alleles in the pair "drops out" so you see the effect on the allele that is left (this is called monoallelism). So, if we imagine a simple case of an animal that is WT het Albino, if the WT allele "drops out" all that is left is the Albino allele and the tissue patches in the "drop out" area will look Albino.
Now, if we posit that this animal here is a mosaic and not a chimera then genetically the animal would have to be a Yellowbelly het Albino and we would be seeing the Ivory phenotype from "drop out" of the WT allele at the YB locus and the Albino phenotype from "drop out" of the WT allele at the Albino locus. But you would not see these two separate and independent "drop out" events happening in an alternating pattern giving perfect, discreet regions of each. Instead, we would a more chaotic distribution of "drop outs" where some regions would be phenotypically YB, some areas would be AlbinoYB, some areas would be Ivory, and some areas would be Albino Ivory. We do not see the first and last of those phenotypes in this animal.
Flipside, if we posit that the animal here is a chimera then what you have is a case where there was a fusion event between an AlbinoYB zygote and an Ivory zygote which very easily gives rise to the two discreet and delineated phenotype regions that we are seeing.
Does that make more sense than my earlier gibberish?
Re: Ivory/Albino Paradox? Chimera? What is this thing?
Quote:
Originally Posted by
asplundii
Does that make more sense than my earlier gibberish?
LOL. yeah. you did a pretty good job, thank you. It is sometimes very hard to describe things in layman's terms so I appreciate the effort. I have the same problem when trying to describe engineering concepts.