Can't say enough good things about both. You MAY be able to find a wider range of projectile for the .30-06 than the .308.....MAYBE. Not really sure. Bolt gun, mag fed, or a semi auto in .308 are both excellent calibers for game from yotes all the way up to moose. I may be a big fan of the .270 and like the performance I get with a 130gr Barnes bullet but hey....that because I don't have a .3XXXX fill in the blands yet. Well...I suppose I have a .308Express Marlin so bugger on me...I do have one!