You can actually take a snake out whenever. When you are handling them, they will wake up and become active when handling. Most of the time the snakes won't even come out of their hides until you are asleep. You can handle a snake whenever because they won't have anything personal on you when you wake them up from a nap. Snakes won't put up much of a fight when you wake them up, but the ones that are not handled often would. When you do go in the enclosure to pick up a snake, take away the hide that they are sleeping in and gently pick the snake up so you do not startle it. Sometimes snakes that get startled will get defensive at that moment. You should be fine picking up a snake while it's sleeping, just don't try to startle it.