As others have said it really doesn't hurt at all. Once it does it'll happen it will be so fast you won't even know it til after.
Just don't be hesitant and scared when you're handling them though, it seems like they can pick up on it and get even more defensive. I have a little male that's just a complete jerk, and at first I would try to distract him before I picked him up but that just made him even more nippy. Now I just reach right in and snag him and he doesn't strike at me as much, just hisses and complains but overall seems less defensive.