I went into it deliberately to start a business, so I acquired 3 adult females and a pastel male, and bred them that fall.
I also got a pair of albino hatchlings, a pair of orange ghost hatchlings, and a male spider hatchling.
My goal was for the business to be self-sufficient (initial investment aside) as soon as possible, and I accomplished that fairly quickly. By selling all of the hatchlings, and buying more adult normal females, baby morph males, and racks each year, I built my collection up quickly. Adding some het albino adults also proved to be a great idea. 2010 was our first year for keeping significant numbers of holdbacks. We'll do the same this year, and the year after. 2013 is going to be fun. :)
A lot depends on what your end goal is. If you are doing it as a hobby, get the ones you like, take it slow, and produce what you want. If you are doing it as a business, then consider what will give you the greatest return on your investment, and what will hold its value best. Always remember that if you have hatchling females, you have to feed them for years before you can breed them.