Our little het albino male, Malachi, will hiss if you are removing him from his comfy hide but hey I figure I'd hiss too if I was happily hanging out and some giant grabbed me up LOL. He doesn't strike then but will do so on feeding day but again, I'm happy as that just indicates he's ready to go and has a great feeding response. The only other hisser in the house is one of our females, Kyna, who will occasionally do this slow, quiet hiss if you bother her. I swear it sounds like the equivalent of a snake sigh...as if to say..."lord it's those idiots again" LOL. We call it her "hiss off" hiss.