Prego Mouse?

I would take the male out, as he WILL get your females pregnant IMMEDIATELY after they give birth.. not good on a nursing mother, stressful trying to raise babies, and grow a litter in her while caring for herself too.

Also, you may want to consider getting a bigger enclosure for those mice, a 10 gallon is really not big enough when you consider as it is now, you have 4 adults living together and IMO a 10 gal. is even a bit small for them, once you add babies to the mix, you will risk them killing babies b/c of lack of sufficient space, stress, etc.

Generally, males wont eat "thier own babies", but it does not mean it is not impossible, as I have seen it happen in my own colonies when I bred mice, some males are worse than others about that. I have never had any issues when taking males out, and reintroducing them to the females later.... when I did it, I would do it right after a cage cleaning so it does not smell totally like home to the females, and it feels like a new environment to them all.

You could get a 50qt rubber maid and modify that for use for max of 2 females with babies, 3 maybe... but be prepared to separate babies out rather quickly, so you dont have males and females impregnating eachother. You really want to keep a control on your breeding. To get healthier babies you never want to encourage them to breed with thier own brothers/sisters.

Im not gonna say its the best way, but here is what do. I work for my college's biology department, and we have alot of snakes and raise a LOT of mice and rats. We never separate any of them untill the young are able to survive on their own, then they go in the "feeder" tubs and out of the "breeder" tubs. We keep a male and 2 or 3 females in a tub about the size of a small shoebox. We use corn cob bedding, changed about once a week (about every 4 or 5 days would be better). In my experience as long as they have plenty of food and water they will be fine. We do occasionally lose some babies and the rare adult there and there, but usually from running out of water(not many people around during the summer and some times water gets low). Generally it all works out just fine.

I've been breeding mice for about 6 months, and have always left them all in with the babies - I do 1.2 mice per 10 gallon breeding tank, and the dad's have always helped out with the babies - I've had 1 psycho mom who killed some of the other females, than she was moved to one of the feeder tanks.

For the most part, the females will take care of each others litters as well - One of my breeder groups just recently gave birth to 2 litters in about 3 days of each other, and the females combined the litter into one and both take care feeding the babies...

As said befor you should take the male out as he WILL get the mom pregnant again. This will be very hard on her body and will take away nutrients and energy that she needs to raise her babies.

Also, to help curb the eating of the babies dont peak or bother the mom too much they are first born ( in ow its hard not to want to mess with them).. Let her be for a couple of days especially if she is a new mother. They can get stressed quick and then she will take it out on the babies.

good luck.