Best Substrate For Only 1 Ball Python???

I personally think you shouldn't use aspen or newspaper as they suck for keeping humidity up. I use cocopeat substrate and I filter out the long strands so it has a similar consistency to dirt. In my 6 months of snake keeping, I've never seen a single spot of mold on it, so I can say that it's at least slightly mold resistant.

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I use a blend if eco earth and repti-bark. Holds humidity well, looks good and has worked for me for years. I do adjust the ratio to better achieve desired humidity as the seasons change.

I had big time humidity issues in my exo terra...always at 30-40%....I was using Eco earth. I just switched to a PVC cage and decided to also switch to reptile prime since the Eco earth was a little too chunky for me. Humidity in the new tank is constantly 55-65% with zero misting, etc. I'm quite certain the tank change to PVC from screen top / CHE tank is 95% responsible for the change but I am liking the reptile prime too for sure.