I for one think there is a time and place for it.
There are also certain people you can go further with than others BUT keep in mind that everyone can see your post and those that don't understand might not like it.
I have seen a lot of "smart" responses when someone is asking a genuine question because they don't know any better. These are the ones that irk me.
I will be honest about it, for me it depends who you are and what mood I am in. I can take it as long as you think you can handle what I will throw back at you.;)